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Prednisone for hearing loss. Treating Sudden Hearing Loss Without Side Effects
Oral steroid regimens for idiopathic sudden sensorineural hearing loss.Steroid Treatments Equally Effective Against Sudden Deafness | National Institutes of Health (NIH)
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❾-50%}- Prednisone for hearing loss
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The onset of sudden hearing loss can be the cause of significant stress and worry in the affected individual. Sudden hearing can be the result of numerous different causes. In general, there are two types of hearing loss. One is conductive hearing loss, in which there is a problem getting sound from the environment to the inner ear. In conductive hearing loss, there is typically a problem with the external ear canal, eardrum, or middle ear.
In the second general category of. In the second general category of hearing loss, sensorineural hearing loss, the ear canal, eardrum, and middle ear space are normal. The problem is located in a site out of view of the physical exam, namely the inner ear or nerve to the inner ear. Patients with sudden sensorineural hearing loss SSNHL most commonly present to their physician with a rapid onset of hearing loss, but a normal physical exam of the ear.
SSNHL is not a common problem, in a population ofpeople, between people will develop this type of hearing loss each year [ 12 ]. In the United States, there are reports of up to 66, new cases diagnosed each year [ 2 ]. SSNHL is most commonly defined as a sensorineural hearing loss of at least 30 dB at three frequencies developing over a time period less than a 3 days [ 34 ].
If spontaneous recovery does occur, it most commonly occurs within the two weeks after onset [ 6 ]. In those cases of unknown cause, most are generally thought to be of a virally-mediated process [ 910 ].
Direct sampling of fluid from the inner ear or tissue from the hearing nerve to sample for viruses is not possible without the likely result of irreversible hearing loss. One of the most common symptoms that occurs is a sensation of fullness or pressure in the ear.
This frequently leads patients or primary care doctors to treat patients as if the problem is caused by fluid in the middle ear space. Treatment and the correct diagnosis can be delayed by treatment with unhelpful medications such as antibiotics, decongestants, and nasal sprays.
This involves testing the ability to hear tones and to understand speech. It is one thing to be able to hear tones, but far more important is the ability to hear and understand speech. A tympanogram is performed to assess the mobility of the eardrum to ensure it is appropriately mobile. Hearing loss is best described in terms of a descriptive term such as mild, moderate, moderately-severe, severe and profound.
People are frequently told a percentage of hearing they have lost, which is a complicated calculation that is rarely performed. Another important diagnostic test is an MRI scan. An imaging center must have some expertise to be able to appropriately perform this study with sufficiently high quality, therefore contrast may be required at some centers.
With an open MRI, contrast will also be required. If an MRI cannot be performed as in the case of a pacemakerother studies can be used to lessen the suspicion of a vestibular schwannoma, such as auditory brainstem response testing [ 16 ].
Once the diagnosis of SSNHL is confirmed, a discussion of available treatment options must be carried out with a physician knowledgeable in the disorder. A great number of treatments have been described over time, but most have been found to be unhelpful.
Treatments found to be unhelpful include: antiviral medications [ 17 ], volume expanding agents dextran [ 18 ], and vasodilators [ 19 ]. One possible treatment is no treatment at all, or a period of observation. As described previously, some patient will improve without any medical intervention.
There are some features of the hearing loss that may indicate a favorable result with simple observation. These include a low frequency hearing loss and a mild hearing loss. Most hearing improvement noted with observation is seen within the first two weeks after onset [ 6 ]. Although controversial, the most commonly prescribed treatment for SSNHL is the use of oral steroids. A randomized, placebo-controlled trial in demonstrated two-third of patients treated with steroids showed improvement while only one-third of patients treated with placebo had improvement of their hearing[ 20 ].
Other studies have shown no effect with steroid use [ 2122 ]. Prednisone is typically used at doses ranging from mg daily for days, then a tapering of the dosage over the following days. The optimal dosage of steroid and the time needed for treatment in not defined by any medical study. Steroids are clearly not effective in all patients, as not all patients have improvement with their use. However, some patients are clearly responsive to steroids which is demonstrated in trials of patients receiving steroids injected into the middle ear space discussed below.
Steroids are associated with side-effects that can include: elevation in blood glucose, increased pressure within the eye, hip joint problems with possible need for joint replacement surgery, inability to sleep, weight gain, fluid retention, bone weakening, psychiatric disturbances, among others.
In an ideal situations, steroids would only be prescribed to patients that will benefit from their use, and avoided in those who will improve with no treatment. However, we do not currently have a laboratory test that will demonstrate who will or will not respond to steroids. While treating some patients that will derive benefit, some patients are exposed to the side effects of steroids without hearing benefit.
In our opinion, since major long-term complications of steroids are rare, we feel the benefit of treatment with oral steroids outweighs the risk. Steroids can be delivered to the inner ear by injection of medication through the eardrum into the middle ear. The steroid then passes through a membrane called the round window and into the inner ear. Delivery of steroid by this injection achieves much higher concentrations of steroid within the inner ear than that seen with oral steroid administration [ 2324 ].
In animals, the medicine within the inner ear lasts for less than 24 hours [ 23 ]. For this reason, to maintain a prolonged, adequate dosage of steroid within the inner ear, multiple injections are performed. The steroid injection procedure is well-tolerated and performed in the office. The eardrum is visualized under a microscope, and a small needle is used to inject the medicine into the middle ear.
The patient lies in the exam chair with her head turned for 30 minutes to allow the medicine to diffuse into the inner ear. The patient does her best not to swallow or speak during this period to minimize opening of the eustachian tube. Eventually, the fluid will exit the middle ear via the eustachian tube and run into the back of the nose.
A small amount of steroid is absorbed into the bloodstream, but at much lower concentrations than that seen with oral use. There is a tiny chance that a persistent hole in the eardrum may form. Transtympanic steroids have been shown to be equally effective to oral steroids [ 25 ]. In addition, transtympanic steroids have been shown, in a majority of studies, to be effective in treating patients who have failed to improve with observation, oral steroids alone, or other treatments[ ].
Combination therapy with oral and transtympanic steroids have been shown to be superior to one form of steroid alone [ 30 ]. For most patients, we recommend an initial treatment with a combination of oral and transtympanic steroids for SSNHL. The transtympanic steroids result in a high dose of steroid within the inner ear, and we know a higher dosage of steroid leads to better results [ 31 ].
Because steroid within the inner ear persists for less than 24 hours, we recommend daily injections. We typically recommend a minimum of three injections, but do not have a set maximum of injections, instead we treat until the hearing improvement stabilizes. We utilize oral steroids due to the fact that transtympanic steroids alone will not reach the hearing cochlear nerve. Oral steroids will deliver steroid to the hearing nerve, which may be a site of dysfunction.
By way of this combination, the fluid of the inner ear and the hearing nerve can be treated with steroids to maximize treatment success. Each patient much be treated on an individual basis and only with a thorough examination and history can a treatment regimen be recommended.
Byl, F. Laryngoscope, Alexander, T. Harris, Incidence of sudden sensorineural hearing loss. Otol Neurotol, Stachler, R.
Otolaryngol Head Neck Surg, Conlin, A. Parnes, Treatment of sudden sensorineural hearing loss: I. A systematic review. Arch Otolaryngol Head Neck Surg, Fetterman, B. Luxford, and J. Saunders, Sudden bilateral sensorineural hearing loss. Mattox, D. Simmons, Natural history of sudden sensorineural hearing loss. Ann Otol Rhinol Laryngol, Parnes, Treatment of sudden sensorineural hearing loss: II. A Meta-analysis. Rauch, S.
Idiopathic sudden sensorineural hearing loss. N Engl J Med, Schuknecht, H. Donovan, The pathology of idiopathic sudden sensorineural hearing loss. Arch Otorhinolaryngol, Linthicum, F. Doherty, and K. Berliner, Idiopathic sudden sensorineural hearing loss: vascular or viral? Nakashima, T.
localhost › Connect to Care › Hearing loss. Injecting steroids into the middle ear works just as well as taking them orally when it comes to restoring hearing for sudden deafness. For those with very severe loss, 90 decibels or above, oral steroids proved to be a better treatment. The study, published in the Journal of the. Patients with NF2 can also suffer from sudden onset of hearing loss from Most ENT doctors in the UK would agree that giving high dose oral steroids (up. The National Institutes of Health (NIH) notes that oral steroids, such as prednisone, are. Toggle navigation.Jump to navigation. Sudden hearing loss is a condition characterised by the sudden onset usually within 72 hours of reduced or absent hearing. People have often used corticosteroids — a type of anti-inflammatory medicine - to treat the condition.
These medicines are usually taken by mouth or injected into the body known as systemic corticosteroids , but can also be given as an injection directly into the middle ear, through the eardrum known as intratympanic corticosteroids. It is not clear whether intratympanic treatment with corticosteroids is effective, or which of these treatments intratympanic or systemic is best for treating this condition.
We searched for all relevant studies in the medical literature, compared the results and summarised the evidence. We also assessed how certain the evidence was, considering factors such as study size and the way studies were conducted. Based on our assessments, we categorised the evidence as being of very low, low, moderate or high certainty. We found 30 studies that included people. These studies compared intratympanic treatment with corticosteroids with no treatment, with placebo sham or dummy treatment and with corticosteroids that were taken by mouth or injection into the body systemic corticosteroids.
We took into account whether people were having their first treatment for sudden deafness or whether they had previously had some other kind of treatment which had not worked. We did not find any studies that compared intratympanic corticosteroids to no treatment or placebo dummy treatment.
Intratympanic corticosteroids might result in little or no difference in hearing when compared to people who receive systemic corticosteroids, and might make little to no difference in the number of people whose hearing improves. The side effects may be different with these two types of treatment. With intratympanic treatment, people may have an increase in the risk of dizziness or ear pain as compared to systemic corticosteroids, typically at the time of injection, and some may develop a small hole in the ear drum.
However, systemic treatment may also cause an increased risk of different side effects, such as problems with sugar levels in the blood. Taking intratympanic corticosteroids as well as systemic corticosteroids might result in a small improvement in hearing compared to systemic corticosteroids alone, but it is uncertain how many people would notice an improvement.
As above, intratympanic treatment may cause some side effects, but we cannot be certain of the number of people who may experience these. For people having additional treatment for sudden deafness when their first treatment did not work. When compared to no treatment or a placebo dummy treatment, intratympanic corticosteroids may result in a much larger number of people having an improvement in their hearing but may only improve hearing slightly.
As with first treatment, intratympanic injections might cause some side effects, such as pain or dizziness at the time of the injection, or development of a small hole in the ear drum. We are not certain how often these side effects will happen.
We are very uncertain whether adding intratympanic treatment to systemic treatment will result in an improvement in hearing. We considered most of the evidence we found to be of low or very low certainty.
This was because there were often some problems with how the studies had been carried out, there may have been few people included in the studies and sometimes results from different studies were conflicting.
Therefore, the conclusions of this review may change as new studies are published. Most of the evidence in this review is low- or very low-certainty, therefore it is likely that further studies may change our conclusions. For primary therapy, intratympanic corticosteroids may have little or no effect compared with systemic corticosteroids.
There may be a slight benefit from combined treatment when compared with systemic treatment alone, but the evidence is uncertain. For secondary therapy, there is low-certainty evidence that intratympanic corticosteroids, when compared to no treatment or placebo, may result in a much higher proportion of participants whose hearing is improved, but may only have a small effect on the change in hearing threshold. It is very uncertain whether there is additional benefit from combined treatment over systemic steroids alone.
Idiopathic sudden sensorineural hearing loss ISSNHL is common, and defined as a sudden decrease in sensorineural hearing sensitivity of unknown aetiology. Systemic corticosteroids are widely used, however their value remains unclear. Intratympanic corticosteroids were given as primary or secondary treatment after failure of systemic therapy. Our primary outcome was change in hearing threshold with pure tone audiometry.
Secondary outcomes included the proportion of people whose hearing improved, final hearing threshold, speech audiometry, frequency-specific hearing changes and adverse effects. We included 30 studies, comprising analysed participants. Some studies had more than two treatment arms and were therefore relevant to several comparisons. Studies investigated intratympanic corticosteroids as either primary initial therapy or secondary rescue therapy after failure of initial treatment. Intratympanic corticosteroids versus systemic corticosteroids as primary therapy.
We identified 16 studies participants. Intratympanic therapy may result in little to no improvement in the change in hearing threshold mean difference MD We found little to no difference in the proportion of participants whose hearing was improved risk ratio RR 1.
Intratympanic therapy may result in little to no difference in the final hearing threshold MD Intratympanic therapy may increase the number of people who experience vertigo or dizziness RR 2.
Intratympanic plus systemic corticosteroids combined therapy versus systemic corticosteroids alone as primary therapy. We identified 10 studies participants.
Combined therapy may have a small effect on the change in hearing threshold MD The evidence is very uncertain as to whether combined therapy changes the proportion of participants whose hearing is improved RR 1. Combined therapy may result in slightly lower more favourable final hearing thresholds but the evidence is very uncertain, and it is not clear whether the change would be important to patients MD Some adverse effects only occurred in those who received combined therapy.
Intratympanic corticosteroids versus no treatment or placebo as secondary therapy. We identified seven studies participants. Intratympanic therapy may have a small effect on the change in hearing threshold MD Intratympanic therapy may result in a much higher proportion of participants whose hearing is improved RR 5.
Intratympanic therapy may result in lower more favourable final hearing thresholds MD Some adverse effects only occurred in those who received intratympanic injection. Intratympanic plus systemic corticosteroids combined therapy versus systemic corticosteroids alone as secondary therapy.
We identified one study with 76 participants. Change in hearing threshold was not reported. Combined therapy may result in a higher proportion with hearing improvement, but the evidence is very uncertain RR 2.
Adverse effects were poorly reported with only data for persistent tympanic membrane perforation rate 8. Treatment of sudden hearing loss with corticosteroids applied into the middle ear What is sudden hearing loss?
How is it treated? What did we want to find out? What did we do? What did we find? For people having their first treatment for sudden deafness We did not find any studies that compared intratympanic corticosteroids to no treatment or placebo dummy treatment. For people having additional treatment for sudden deafness when their first treatment did not work When compared to no treatment or a placebo dummy treatment, intratympanic corticosteroids may result in a much larger number of people having an improvement in their hearing but may only improve hearing slightly.
What are the limitations of the evidence? How up-to-date is this evidence? The evidence in this Cochrane Review is current to 23 September Authors' conclusions:. Search strategy:. Selection criteria:. Data collection and analysis:. Main results:. Intratympanic corticosteroids versus systemic corticosteroids as primary therapy We identified 16 studies participants.
Intratympanic plus systemic corticosteroids combined therapy versus systemic corticosteroids alone as primary therapy We identified 10 studies participants. Intratympanic corticosteroids versus no treatment or placebo as secondary therapy We identified seven studies participants.
Intratympanic plus systemic corticosteroids combined therapy versus systemic corticosteroids alone as secondary therapy We identified one study with 76 participants. Health topics:.
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