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Prednisone oral solution. Prednisone oral solution
prednisone 5 mg/5 mL oral solution | Kaiser Permanente - You are here
What should I tell my health care provider before I take this medicine? They need to know if you have any of these conditions: Cushing's syndrome diabetes glaucoma heart disease high blood pressure infection especially a virus infection such as chickenpox, cold sores, or herpes kidney disease liver disease mental illness myasthenia gravis osteoporosis seizures stomach or intestine problems thyroid disease an unusual or allergic reaction to prednisone, other corticosteroids, medicines, foods, dyes, or preservatives pregnant or trying to get pregnant breast-feeding.
What should I watch for while using this medicine? NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Sign up here! Yes, I agree to the privacy policy.
Wellness Library. The questions you should be asking your doctor during your annual wellness exam. By Cynthia Alexander, MD. Mount Nittany Physician Group. Lanadelumab injection. Cocaine topical solution or spray. Methadone tablets. Zileuton tablets. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
To do so may increase the chance for unwanted effects. This medicine comes with a patient instruction insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions. Measure the oral liquid with the special oral syringe that comes with the package. The average household teaspoon may not hold the right amount of liquid. If you use this medicine for a long time, do not suddenly stop using it without checking first with your doctor.
From these stock solutions, standard solutions were prepared and diluted in methanol to the development, optimization and validation of the analytical method. The experimental procedure was as follows: An accurately weighed portion of 0. Ultrasound was applied during 5 minutes. The solution was filtered and centrifuged, and the supernatant was injected. After that, Prednisone standard was added to achieve every concentration level. These simulated samples were analyzed on five different days to develop the recovery and reproducibility study, and on one day to repeatability study.
Thus, the found concentration after the analysis was compared to the added amount of standard Prednisone at the three different levels. The content of Prednisone in the pharmaceutical product was determined according to the sample preparation protocol described at point 2.
The chemical stability indicating capability of the HPLC method was demonstrated by forced degradation of Prednisone drug substance at concentration 0.
The kinetic parameters were determinated according to the plot obtained from the accelerated stability study Remaining percentage of Prednisone oral suspension against the time. To optimize the chromatographic method, three mobiles phases at different rates flow and two stationeries phases were tested using a standard solution of Prednisone at concentration 0.
The efficiency of the chromatographic method is expressed in terms of Height Equivalent Plate Theory HEPT and tailing factor; tables 1 , 2 and 3 show the obtained data. The experimental methodology was validated according to the ICH guidelines for validation of analytical procedures. The intraday precision was determined with the simulated pharmaceutical samples of Prednisone oral suspension described on point 2.
The interday precision was determined for the same simulated pharmaceutical samples by comparison of the analytical results on five different days.
Table 4 shows the results in terms of the relative standard deviation RSD. The recovery study was evaluated in terms of recovery percentage of Prednisone based on the same simulated pharmaceutical samples described on point 2. Table 5 shows these results. Detection limit was 0. The specificity of the method was evaluated through possible interferences caused by oral suspension ingredients. Figures 3 and 4 show that there is not interference between Prednisone and its degradation products obtained by forced degradation at acid and basic conditions.
According to the results, Prednisone drug substance is more susceptible to alkaline forced degradation five degradation products. An important condition to be considered during the drug product's manufacturing process, in this case an oral suspension. This medication may mask signs of infection. It can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others such as chickenpox, measles, flu.
Consult your doctor if you have been exposed to an infection or for more details. Ask your doctor or pharmacist about using this product safely. Avoid contact with people who have recently received live vaccines such as flu vaccine inhaled through the nose.
This medicine may cause stomach bleeding. Daily use of alcohol while using this medicine may increase your risk for stomach bleeding. Limit alcoholic beverages. Consult your doctor or pharmacist for more information. This medication may slow down a child's growth if used for a long time.
Consult the doctor or pharmacist for more details. See the doctor regularly so your child's height and growth can be checked. During pregnancy, this medication should be used only when clearly needed. It may rarely harm an unborn baby.
Discuss the risks and benefits with your doctor. Infants born to mothers who have been using this medication for an extended period of time may have hormone problems. This medication passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding. Drug interactions may change how your medications work or increase your risk for serious side effects.
This document does not contain all possible drug interactions. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Short report. Crushed prednisolone tablets or oral solution for acute asthma? Abstract In a randomised trial, treatment with prednisolone in two formulations oral solution or crushed tablets was compared in 78 young children with acute asthma. Statistics from Altmetric. Methods and results Seventy eight children 48 boys , aged 3 months to 8 years mean age 24 months , presenting to our hospital with acute severe asthma and no other significant illness, in whom the attending physician considered treatment with systemic steroids indicated, participated in the study.
Figure 1 Change in dyspnoea VAS score during treatment with prednisolone oral solution or crushed tablets. Discussion This study shows that prednisolone oral solution is better tolerated than crushed tablets in the treatment of acute severe asthma in children. Thorax 52 suppl 1 : S2 — S Provisional Committee on Quality Improvement Practice parameter: the office management of acute exacerbations of asthma in children. Pediatrics 93 : — Dawson KP , Sharpe C A comparison of the acceptability of prednisolone tablets and prednisolone sodium phosphate solution in childhood acute asthma.
Aust J Hosp Pharm 23 : — Am J Dis Child : —
An accelerated chemical stability study of Prednisone oral suspension has been performed during 6 months. Prednisolone was used as internal standard. Prednisone drug substance was subjected to forced degradation by acid and basic hydrolysis and oxidation condition, UV-Vis radiation effect, temperature and relative humidity were studied to demonstrate the indicating capability of the chromatographic method.
Two and five degradation products were detected at acid and basic forced degradation respectively. No degradation products were detected at the others studied conditions. One degradation product from Prednisone oral suspension was detected during the accelerated chemical stability study. The proposed method was adequate to determine Prednisone drug substance, Prednisone oral suspension and their degradation products.
The kinetic parameters of Prednisone oral suspension under the studied conditions are also reported. Stability is an essential quality attribute for drug products. The rate at which drug products degrade varies dramatically; some products must be used within a day. Other products may, if properly stored and packaged, retain integrity for years.
Therefore it's necessary to evaluate the physical, chemical and microbiological changes at the shelf life of the pharmaceutical products to ensure their stability.
Associated with those changes, may appear potentially adverse effects, loss of activity, increase in concentration of active, alteration in bioavailability, loss of content uniformity, decline of microbiological status, loss of pharmaceutical elegance and patient acceptability and formation of toxic degradation products. In recent years, rigorous quality control processes in the pharmaceutical industry has given raise to a growing need for simple, selective and sensitive analytical methods to the study of degradation products as well as impurities; in order to assure the quality of the drug substance or drug product.
Glucocorticoids are widely used to treat various inflammatory and immunological diseases. Also, its immunosuppressant effect is useful to transplanted patients. The official method of the United States Pharmacopoeia is based on liquid chromatography and it is not a stability indicating method. The objective of this work was to study and evaluate the chemical behavior of Prednisone oral suspension and drug substance using exaggerated storage conditions throughout an adequate chromatographic stability indicating method.
Baker, N. The data acquisition software was Varian Star Chromatography Workstation 6. From these stock solutions, standard solutions were prepared and diluted in methanol to the development, optimization and validation of the analytical method.
The experimental procedure was as follows: An accurately weighed portion of 0. Ultrasound was applied during 5 minutes. The solution was filtered and centrifuged, and the supernatant was injected.
After that, Prednisone standard was added to achieve every concentration level. These simulated samples were analyzed on five different days to develop the recovery and reproducibility study, and on one day to repeatability study. Thus, the found concentration after the analysis was compared to the added amount of standard Prednisone at the three different levels.
The content of Prednisone in the pharmaceutical product was determined according to the sample preparation protocol described at point 2. The chemical stability indicating capability of the HPLC method was demonstrated by forced degradation of Prednisone drug substance at concentration 0. The kinetic parameters were determinated according to the plot obtained from the accelerated stability study Remaining percentage of Prednisone oral suspension against the time. To optimize the chromatographic method, three mobiles phases at different rates flow and two stationeries phases were tested using a standard solution of Prednisone at concentration 0.
The efficiency of the chromatographic method is expressed in terms of Height Equivalent Plate Theory HEPT and tailing factor; tables 12 and 3 show the obtained data.
The experimental methodology was validated according to the ICH guidelines for validation of analytical procedures. The intraday precision was determined with the simulated pharmaceutical samples of Prednisone oral suspension described on point 2.
The interday precision was determined for the same simulated pharmaceutical samples by comparison of the analytical results on five different days. Table 4 shows the results in terms of the relative standard deviation RSD.
The recovery study was evaluated in terms of recovery percentage of Prednisone based on the same simulated pharmaceutical samples described on point 2. Table 5 shows these results. Detection limit was 0. The specificity of the method was evaluated through possible interferences caused by oral suspension ingredients. Figures 3 and 4 show that there is not interference between Prednisone and its degradation products obtained by forced degradation at acid and basic conditions. According to the results, Prednisone drug substance is more susceptible to alkaline forced degradation five degradation products.
An important condition to be considered during the drug product's manufacturing process, in this case an oral suspension. No degradation products were detected at oxidation condition, UV-Vis radiation and temperature exposure for Prednisone drug substance in solution and solid state respectively. Figure 5 describes this situation. The degradation of Prednisone in both cases glass and plastic packagefollowed a zero order of reaction according to the plot obtained from the accelerated stability study.
Table 8 shows the kinetic parameters under the exaggerated studied conditions. A liquid chromatographic method to determine Prednisone drug substance and oral suspension was developed.
The developed method was validated satisfactorily in terms of linearity, repeatability and reproducibility, recovery percentage, detection limit, quantitation limit and specificity. The developed and validated liquid chromatographic method demonstrated to be indicator of chemical stability for Prednisone drug substance and Prednisone drug product oral suspension.
An accelerated stability study was performed to Prednisone oral suspension during 6 months. One degradation product of Prednisone oral suspension was detected during the accelerated stability study. Carstensen, C. Rhodes, Drug Stability Principles and Practices, 3 rd ed. Brain-Isasi, C.
Requena, A. Amendola F. Garribba, F. Acta, Sweetman, Martindale The complete drug reference, 3 rd ed. New Jersey, Andersen, L. Hansen, M. Pedersen, Anal. DiFrancesco, V. Frerichs, J. Donnelly, C. Hagler, J. Hochreiter, K. Tornatore, J. B42, Frerichs, K. B, Gaillard, M. Lhermitte, G. Shibata, T. Hayakawa, K. Takada, N. Hoshino, T. Monouchi, A. Yamaji, J. Santos-Montes, R. Gonzalo-Lumbreras, R. Izquierdo-Hornillo, J. B27, Volin, J.
Taylor, S. Grebe, R. Singh, Clin. Ali, M. Ghori, A. Saeed, J. Liu, S. Chen, S. Wu, H. Kou, H. Wu, J. A, Santoro, E.
Prednisolone Dompé mg/ml oral solution contains the equivalent of mg/ml of prednisolone in the form of the disodium phosphate ester. Prednisolone. Prednisolone is a man-made form of a natural substance (corticosteroid hormone) made by the adrenal gland. It is used to treat conditions such as arthritis. PREDNISOLONE (pred NISS oh lone) treats many conditions such as asthma, allergic reactions, arthritis, inflammatory bowel diseases, adrenal, and blood or bone. Prednisolone sodium (prednisolone sodium phosphate oral solution) phosphate, USP, oral solution is a dye free, colorless to light straw colored, raspberry. The proposed method was adequate to determine Prednisone drug substance, Prednisone oral suspension and their degradation products. The kinetic parameters of. Six to eight days after the initial visit, patients were seen by a paediatric pulmonologist, who had not seen the patient at the initial visit, and was unaware of the prednisolone formulation received. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Dawson KPSharpe C A comparison of the acceptability of prednisolone tablets and prednisolone sodium phosphate solution in childhood acute asthma. This medicine may increase blood sugar. To prevent these symptoms while you are stopping treatment with this drug, your doctor may reduce your dose gradually. The interday precision was determined for the same simulated pharmaceutical samples by comparison of the analytical results on five different days.It is commonly used to treat inflammation of the skin, joints, lungs, and other organs. Common conditions treated include asthma, allergies, and arthritis. It is also used for other conditions, such as blood disorders and diseases of the adrenal glands. Take this medicine by mouth. Use a specially marked spoon or dropper to measure your dose. Ask your pharmacist if you do not have one. Do not use a household spoon. Follow the directions on the prescription label. Take with food or milk to avoid stomach upset.
If you are taking this medicine once a day, take it in the morning. Do not take more medicine than you are told to take. Do not suddenly stop taking your medicine because you may develop a severe reaction. Your doctor will tell you how much medicine to take.
If your doctor wants you to stop the medicine, the dose may be slowly lowered over time to avoid any side effects. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. Side effects that you should report to your doctor or health care professional as soon as possible:. Side effects that usually do not require medical attention report to your doctor or health care professional if they continue or are bothersome :. If you miss a dose, take it as soon as you can.
If it is almost time for your next dose, talk to your doctor or health care professional. You may need to miss a dose or take an extra dose.
Do not take double or extra doses without advice. Store at room temperature between 15 and 30 degrees C 59 and 86 degrees F. Protect from light. Keep container tightly closed. Throw away any unused medicine after the expiration date. Visit your doctor or health care professional for regular checks on your progress. If you are taking this medicine over a prolonged period, carry an identification card with your name and address, the type and dose of your medicine, and your doctor's name and address.
This medicine may increase your risk of getting an infection. Tell your doctor or health care professional if you are around anyone with measles or chickenpox, or if you develop sores or blisters that do not heal properly. If you are going to have surgery, tell your doctor or health care professional that you have taken this medicine within the last twelve months.
Ask your doctor or health care professional about your diet. You may need to lower the amount of salt you eat. This medicine may increase blood sugar. Ask your healthcare provider if changes in diet or medicines are needed if you have diabetes. To our team, you're more than just a number. We see you. And we're committed to you. Our experienced providers are here and ready to get you the care you need.
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Call Us Prednisone oral solution. May 07, Prednisone oral solution What is this medicine? How should I use this medicine? What side effects may I notice from receiving this medicine? Side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue changes in emotions or moods changes in vision depressed mood eye pain fever, chills, cough, sore throat, pain or difficulty passing urine signs and symptoms of high blood sugar such as being more thirsty or hungry or having to urinate more than normal.
You may also feel very tired or have blurry vision. What may interact with this medicine? Do not take this medicine with any of the following medications: metyrapone mifepristone This medicine may also interact with the following medications: amphotericin B aspirin and aspirin-like medicines barbiturates certain medicines for diabetes, like glipizide or glyburide cholestyramine cholinesterase inhibitors cyclosporine digoxin diuretics ephedrine female hormones, like estrogens and birth control pills isoniazid ketoconazole NSAIDS, medicines for pain and inflammation, like ibuprofen or naproxen phenytoin rifampin toxoids vaccines warfarin.
What if I miss a dose? Where should I keep my medicine? Keep out of the reach of children in a container that small children cannot open. What should I tell my health care provider before I take this medicine? They need to know if you have any of these conditions: Cushing's syndrome diabetes glaucoma heart disease high blood pressure infection especially a virus infection such as chickenpox, cold sores, or herpes kidney disease liver disease mental illness myasthenia gravis osteoporosis seizures stomach or intestine problems thyroid disease an unusual or allergic reaction to prednisone, other corticosteroids, medicines, foods, dyes, or preservatives pregnant or trying to get pregnant breast-feeding.
What should I watch for while using this medicine? NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Sign up here! Yes, I agree to the privacy policy. Wellness Library. The questions you should be asking your doctor during your annual wellness exam.
By Cynthia Alexander, MD. Mount Nittany Physician Group. Lanadelumab injection. Cocaine topical solution or spray. Methadone tablets. Zileuton tablets. Search Wellness Articles. Browse by Condition. Find a Provider. Our Locations. Employee Access. All Rights Reserved. Patient Privacy. Patient Safety and Rights.
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